Publications

A full list of Kristina Haslinger’s publications can be found on GoogleScholar.

1. Sokolova N, Denisov SS, & Haslinger K# (2025). Predicting substrate specificity in fungal type III polyketide synthases. Methods in Enzymology (in press)
   doi: 10.1016/bs.mie.2025.11.001
2. Li X, del Carmen Flores-Vallejo R, He T, van Dijl JM, & Haslinger K# (2025). Integrating genomics and metabolomics to accelerate the discovery of anti-MRSA natural products from the endophytic fungus Neocucurbitaria sp. VM-36.
   (BioRxiv: 10.1101/2025.10.09.681339) 
3. Peng B, Wang Z, Zhang L, Groves MR, & Haslinger K# (2025). De novo biosynthesis of alpinetin enhanced by directed evolution of 5-O-methyltransferase.
   (BioRxiv: 10.1101/2025.07.06.663367)
4. Brons JK, Hackl T, Iacovelli R, Haslinger K, Lequime S, van der Meij SET# (2025). De novo whole genome assembly of the globally invasive green shore crab Carcinus maenas (Linnaeus, 1758) via long-read Oxford Nanopore MinION sequencing. Journal of Heredity, esaf085
   doi: 10.1093/jhered/esaf085
   (BioRxiv: 10.1101/2025.05.19.654951)
5. He T*, Li X*, del Carmen Flores-Vallejo R, Radu AM, van Dijl JM, & Haslinger K# (2025). The endophytic fungus Cosmosporella sp. VM-42 from Vinca minor is a source of bioactive compounds with potent activity against drug-resistant bacteria. Current Research in Microbial Sciences, 8, 100390
   doi: 10.1016/j.crmicr.2025.100390
   (BioRxiv: 10.1101/2024.12.27.630490)
6. Sokolova N, Osipyan A, Zhang L, Groves M R, Schmidt S, & Haslinger K# (2024). A biocatalytic platform for the production of substituted 2-quinolones and (thio)coumarins. The FEBS Journal (in press)
   doi: 10.1111/febs.70376
   (BioRxiv: 10.1101/2024.12.20.629698)
7. Sokolova N, Denisov S S, Hackl T, & Haslinger K# (2025). Unravelling the functional diversity of type III polyketide synthases in fungi. Angewandte Chemie, 64(44), e202514786
   doi: 10.1002/anie.202514786
   (BioRxiv: 10.1101/2024.11.25.625244)
8. Hackl T#, Ankenbrand M, van Adrichem B, Wilkins D, & Haslinger K (2024). gggenomes: effective and versatile visualizations for comparative genomics
   (arXchiv: arXiv:2411.13556)
9. Iacovelli R, Poon F, & Haslinger K# (2024). Identification and partial reconstitution of the biosynthetic pathway of bioactive meroterpenoids from Hericium erinaceus (Lion’s Mane mushroom). Molecules, 29(23), 5576
   doi: 10.3390/molecules29235576
   (BioRxiv: 10.1101/2024.07.16.603773)
10. Iacovelli R, He S, Sokolova N, Fodran P, & Haslinger K# (2024). Discovery and heterologous expression of functional 4-O-dimethylallyl-L-tyrosine synthases from lichen-forming fungi. Journal of Natural Products, 87(9), 2243–2254
    doi: 10.1021/acs.jnatprod.4c00619
    (BioRxiv: 10.1101/2024.03.23.586307)
11. Sokolova N, & Haslinger K# (2024). Jasmine scent from engineered microbes. Nature Chemical Engineering, 1, 201-202
    doi: 10.1038/s44286-024-00036-2
12. Iacovelli R, He T, Allen J, Hackl T, & Haslinger K# (2024). Genome sequencing and molecular networking analysis of the wild fungus Anthostomella pinea reveal its ability to produce a diverse range of secondary metabolites. Fungal Biology and Biotechnology, 11:1
    doi: 10.1186/s40694-023-00170-1
    (BioRxiv:10.1101/2023.10.20.563261)
13. Peng B*, Dai L*, Iacovelli R, Driessen AJM#, & Haslinger K# (2023). Heterologous naringenin production in the filamentous fungus Penicillium rubens. Journal of Agricultural and Food Chemistry, 71(51): 20782-20792
    doi: 10.1021/acs.jafc.3c06755
    (BioRxiv:10.1101/2023.09.18.558247)
14. Peng B, Zhang L, He S, Oerlemans R, Quax WJ, Groves MR, & Haslinger, K# (2024) Engineering a plant polyketide synthase for the biosynthesis of methylated flavonoids. Journal of Agricultural and Food Chemistry, 72(1): 529-539
    doi: 10.1021/acs.jafc.3c06785)
    (BioRxiv: 10.1101/2022.10.02.510496)
15. Sokolova N, Peng B, & Haslinger K# (2023). Design and engineering of artificial biosynthetic pathways—where do we stand and where do we go? FEBS Letters, 597(23):2897-2907
    doi: 10.1002/1873-3468.14745
16. He T, Li X, Iacovelli R, Hackl T, & Haslinger K# (2023). Genomic and Metabolomic Analysis of the Endophytic Fungus Fusarium sp. VM-40 Isolated from the Medicinal Plant Vinca minor. Journal of Fungi, 9(7), 704.
    doi: 10.3390/jof9070704
17. Sokolova N, Zhang L, Deravi S, Oerlemans R, Groves MR, & Haslinger K# (2023). Structural characterization and extended substrate scope analysis of two Mg²⁺-dependent O-methyltransferases from bacteria. ChemBioChem 24, e20230007.
    doi: 10.1002/cbic.202300076
18. Iacovelli R, Sokolova N, & Haslinger K# (2022) Striving for sustainable biosynthesis: discovery, diversification, and production of antimicrobial drugs in Escherichia coli. Biochemical Society Transactions 50:1315–28.
    doi: 10.1042/BST20220218.2
19. Terlouw BR, Blin K, Navarro-Muñoz JC, Avalon NE, Chevrette MG, Egbert S, et al. (2023) MIBiG 3.0: a community-driven effort to annotate experimentally validated biosynthetic gene clusters. Nucleic Acids Research, 61(D6): D603–D610.
    doi: 10.1093/nar/gkac1049.3.
20. Haslinger K*# & Schmidt S* (2022). Trendbericht Biochemie 2022: Späte Funktionalisierung mit Biokatalysatoren aus Naturstoffsynthesen. Nachrichten aus der Chemie 70(7-8), 62-65.
    doi: 10.1002/nadc.20224127080
21. Zhou X, Suo F, Haslinger K#, and Quax WJ# (2022). Artemisinin-Type Drugs in Tumor Cell Death: Mechanisms, Combination Treatment with Biologics and Nanoparticle Delivery. Pharmaceutics 14, 395.
    doi: 10.3390/pharmaceutics14020395.
22. Sagita R, Quax WJ, & Haslinger K# (2021). Current State and Future Directions of Genetics and Genomics of Endophytic Fungi for Bioprospecting Efforts. Frontiers in Bioengineering and Biotechnology, 9.
    doi: 10.3389/fbioe.2021.649906.
23. Haslinger K#, Hackl T, & Prather KLJ# (2021). Rapid in vitro prototyping of O-methyltransferases for applications in recombinant pathways in Escherichia coli. Cell Chemical Biology, 28(6): P876-886.E4.
    doi: 10.1016/j.chembiol.2021.04.010
    (BioRxiv: 10.1101/2020.08.27.258715)
24. Cleto S, Haslinger K, Prather KLJ, & Lu TK (2021). Natural combinatorial genetics and prolific polyamine production enable siderophore diversification in Serratia plymuthica. BMC Biology, 19(1), 46.
    doi: 10.1186/s12915-021-00971-z
25. Haslinger K, & Prather KLJ (2020). Heterologous caffeic acid biosynthesis in Escherichia coli is affected by choice of tyrosine ammonia lyase and redox partners for bacterial Cytochrome P450. Microbial Cell Factories, 19(26).
    doi: 10.1186/s12934-020-01300-9
    (BioRxiv: 10.1101/707828)
26. Haslinger K & Prather KLJ (2017). Pathway towards renewable chemicals. Nature Microbiology, 2(12), 1580–1581.
    doi: 10.1038/s41564-017-0071-9
27. Haslinger K#, & Cryle MJ# (2016). Structure of OxyAtei : completing our picture of the glycopeptide antibiotic producing Cytochrome P450 cascade. FEBS Letters, 590(4), 571–581.
    doi: 10.1002/1873-3468.12081
28. Peschke M*, Haslinger K*, Brieke C, Reinstein J, & Cryle MJ (2016). Regulation of the P450 oxygenation cascade involved in glycopeptide antibiotic biosynthesis. Journal of the American Chemical Society, 138(21), 6746–6753.
    doi: 10.1021/jacs.6b00307
29. Brieke C, Kratzig V, Haslinger K, Winkler A, & Cryle MJ (2015). Rapid access to glycopeptide antibiotic precursor peptides coupled with cytochrome P450-mediated catalysis: towards a biomimetic synthesis of glycopeptide antibiotics. Organic & Biomolecular Chemistry, 13(7), 2012–2021.
    doi: 10.1039/c4ob02452d
30. Brieke C*, Peschke M*, Haslinger K, & Cryle MJ (2015). Sequential In Vitro Cyclization by Cytochrome P450 Enzymes of Glycopeptide Antibiotic Precursors Bearing the X-Domain from Nonribosomal Peptide Biosynthesis. Angewandte Chemie – International Edition, 54(52), 15715–15719.
    doi: 10.1002/anie.201507533
31. Haslinger K, Redfield C, & Cryle MJ (2015). Structure of the terminal PCP domain of the non-ribosomal peptide synthetase in teicoplanin biosynthesis. Proteins, 83(4), 711–721.
    doi: 10.1002/prot.24758
32. Haslinger K*, Peschke M*, Brieke C, Maximowitsch E, & Cryle MJ (2015). X-domain of peptide synthetases recruits oxygenases crucial for glycopeptide biosynthesis. Nature, 521(7550), 105–109.
    doi: 10.1038/nature14141
33. Haslinger K, Maximowitsch E, Brieke C, Koch A, & Cryle MJ (2014). Cytochrome P450 OxyBtei Catalyzes the First Phenolic Coupling Step in Teicoplanin Biosynthesis. ChemBioChem, 15(18), 2719–2728.
    doi: 10.1002/cbic.201402441
34. Haslinger K, Brieke C, Uhlmann S, Sieverling L, Süssmuth RD, & Cryle MJ (2014). The Structure of a Transient Complex of a Nonribosomal Peptide Synthetase and a Cytochrome P450 Monooxygenase. Angewandte Chemie International Edition, 53(32), 8518–8522.
    doi: 10.1002/anie.201404977
35. Haslinger K, Brieke C, Uhlmann S, Sieverling L, Süssmuth RD, & Cryle MJ (2014). Die Struktur eines transienten Komplexes einer nicht-ribosomalen Peptidsynthetase mit einer P450-Monooxygenase. Angewandte Chemie, 126(32): 8658-8662.
    doi: 10.1002/ange.201404977
36. Cryle MJ#, Brieke C, & Haslinger K (2013). Oxidative transformations of amino acids and peptides catalysed by Cytochromes P450. In E. Farkas & M. Ryadnov (Eds.), Amino Acids, Peptides and Proteins (38th ed., Vol. 38, pp. 1–36). Cambridge: The Royal Society of Chemistry.
    doi: 10.1039/9781849737081

*authors contributed equally to this work
#corresponding author